The GeneCards Knowledgebase is a powerful integrated biomedical database, expertly integrated from over 190 data sources and incorporating data from thousands of scientific journals. It powers the renowned GeneCards (www.genecards.org) and MalaCards (www.malacards.org) websites, with an ever-growing community of more than 5 Million researchers and clinicians, propelling innovation and discoveries across the biomedical realm.

The GeneCards Suite is used by world-class global consulting firms, top tier pharma-biotech, as well as elite academic institutions pushing the scientific frontier.

Key Features

• Integrated Data Fusion: Harnesses the power of over 190 diverse data sources, offering an all -encompassing biomedical perspective – a treasure trove of multi-dimensional insights.
• Full Context Relationship Annotation: Explores connections between myriad biological entities, annotated with links to sources and referenced publications.
• Robust Biological Entity Integration: Seamlessly translates entity identifiers to integrate with existing workflows. We take care of data gathering, structuring, cleanup and de-duplication.
• Support for Direct & NLP-based Relationships: Paves the way for groundbreaking discoveries by exploring curated and direct as well as inferred relationships between entities.
• Regular Refresh: Quarterly updated to stay in sync with the latest scientific revelations.
• Intuitive Use: Expertly designed, universally understood.

Comprehensive Use Case Coverage

• Target Discovery & Validation: Expedite the identification and confirmation of novel therapeutic targets, laying the groundwork for transformative medicine.
• Machine Learning & AI Training: Empower your AI systems with unparalleled data richness.
• Knowledge Graph Building: Craft knowledge infrastructures rooted in accuracy and evidence-based annotations.
• Clinical Diagnosis: Decipher whole genomes to illuminate links to disease and health.
• Prior Art Research: Validate and protect groundbreaking innovations.

Flexible and Diverse Data Formats

We recognize the myriad ways in which biomedical data can be utilized. To ensure seamless integration into your unique workflows, we offer a curated selection of optimized data formats for a set of diverse applications and systems:

• Raw Datasets: Ideal for researchers and institutions that prefer to dive deep and manipulate data firsthand using standardized data formats including JSON, CSV and Excel.
• Structured Database: Expertly structured, the GeneCards relational database ensures a smooth analytical experience, and facilitates effortless importing into graph knowledgebases and AI systems.
• API Access: Integrate GeneCards data directly into your applications, tools or platforms, with our easy-to-use Application Programming Interface.
• Custom Data Feeds: Need something specific? We provide custom data solutions tailored to match your precise requirements.

Your research and applications deserve data that’s both comprehensive and accessible. With GeneCards, you can receive data the way you need, driving efficiency and innovation in every endeavor.

Gene-Phenotype Associations: Beyond Traditional Boundaries

The GeneCards Suite’s VarElect stands as a beacon of comprehensive understanding for gene-phenotype relationships, pushing beyond traditional constraints to deliver incomparable insights.

To date, VarElect has been used in diagnosis of more than 100,000 exome and whole genome cases.

Key features and applications:

• Ontology-Free Phenotyping: VarElect is not bound by specific ontologies, and allows exploration of genes and regulatory regions, and their association with any biological term.
• Direct Associations: VarElect uncovers explicit, known relationships, integrated from GeneCards’ myriad data sources, between genes and phenotypes, and offers association ranking combined with relevant source evidence.
• Indirect & Inferred Associations: VarElect allows you to delve deeper into gene-phenotype associations through intermediary genes, as well as text-mined associations, illuminating the intricate tapestry of biological interconnections.
• API Integration for Continuous Insight: Leverage our dedicated API for integration into advanced research instruments, AI models, or knowledge graphs.
• Whole genome interpretation: Discover the multifaceted relationships between regulatory elements, mutations, and phenotypes with the combined prowess of GeneHancer and VarElect. Navigate genetic intricacies with unmatched precision and clarity.